Clinical significance of detecting C reaction protein and arterial blood-gas analysis in patients at the acute exacerbation of chronic obstructive pulmonary disease

Objective: To explore the clinical value of detecting C reaction protein(CRP) and arterial blood-gas analysis(ABG) in patients at the acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods: The levels of CRP and ABG in 45 patients with AECOPD were detected before and after treatment,and the results were compared with those of 35 controls.CRP was determined with immune turbidimetry method,and ABG was detected by i-STAT blood-gas analyzer's performance.Results: The serum concentration of CRP of the AECOPD patients was higher than that of the control before and after treatment(P<0.01).After treatment,PaO₂ in AECOPD patients increased significantly,while PaCO₂ decreased(P<0.01).Conclusions: There are obvious changes of the serum concentrations of CRP,ABG in AECOPD patients before and after treatment.Serum concentration of CRP and ABG may act as indicators of curative effect and prognosis,which will provide some laboratory evidence for clinical assessment.