Effects of different target concentrations of sufentanil on the stress response to general anestbesia of hypertension patients tracheal intubation

Objective: To study the effect of different target concentrations of sufentanil on the stress response to the hypertension patients tracheal intubation during induction of general anesthesia. Methods: Sixty hypertension patients were randomly divided into three groups with 20 cases each. Each group received a sufentanil target concentration(STC) of 0.2 ng/ml(S1),0.4 ng/ml(S2) and 0.6 ng/ml(S3),respectively. Mean arterial pressure(MAP),heart rate(HR),and bispectral index(BIS) were recorded at the time points of record baseline(T₀),immediately before intubation(T₁),immediately after intubation(T₂),1 min after intubation(T₃),3 min after intubation(T₄). Results: Compared to T₀ point,Map and HR of S2 and S3 were decreased(P < 0.05-P < 0.01); MAP and HR of S2 were all significant increased at T₂,T₃,T₄ point(P < 0.01), and of S3 at T₃,T₄ were signicantly decreased. Compared with T₀ point,BIS value of three groups were all decresed(P < 0.01),in which were in 45-55 range at T₁,T₂,T₃,T₄ of S2. BIS value of S1 were higher than 55 and of S3 were lower than 45,indicating too shallow or deep anesthesia. Comparison of norepinephrine (NE) concentration:T₀ compared,S1,S2,S3 at each time point was no significant difference(P > 0.05). Comparison with epinephrine(E) concentration:compared with T₀,T₃ of S1 was higher(P < 0.05). T₃,T₄ of S3 were always lower than S1(P < 0.05-P < 0.01),the difference was statistically significant. Conclusions: The hemodynamic response to the hypertension patients during induction of general anesthesia is stable as the target concentration of 0.4 ng/ml.