Telomerase activity detection in gallbladder carcinoma and its significance

Objective: To investigate the significance of the expression of telomerase in chronic cholecystitis and gallbladder carcinoma.Methods: The telomerase activity in 22 cases of gallbladder carcinoma and 28 cases of chronic cholecystitis was measured.Results: The positive expression rate of telomerase in the cases with gallbladder carcinoma was 81.8%,but no positive reaction was detected in the cases with chronic cholecystitis.The difference was significant(P<0.005).Telomerase activity was not obviously correlated with the differentiation and lymphatic metastasis of gallbladder carcinoma(P>0.05).Conclusions: Detecting the activity of telomerase is of reference value for the diagnosis of gallbladder carcinoma.