Detection of human papillomavirus in the lymph node of cervical carcinoma and its clinical significance

Objective: To detect the expression of human papillomavirus(HPV) in the lymph node of cervical carcinoma,and to investigate the relationship between the expression of HPV in the lymph node and clinicopathologic parameters of cervical carcinoma.Methods: The expression of HPV in the lymph node of 42 cases of squamous cervical carcinoma was analyzed retrospectively by S-P immunohistochemical method.The association between HPV expression and clinicopathologic parameters of the cervical carcinoma was assessed.Results: The exression of HPV in the lymph node was correlated with the clinical stage and lymph node metastasis of cervical carcinoma(P=0.029 and P<0.05),but was not related to the age of patients(P=1.000).Conclusions: Expression of HPV in lymph node may act as a usefu1 reference index in predicting lymphatic metastasis and prognosis of cervical carcinoma.