Observation of the clinical features and treatment of malignant lymphoma of the nasal cavity and paranasal sinuses

Objective: To explore the clinical characteristics and efficacy of different therapies for malignant lymphoma of the nasal sinus,and to provide scientific evidence for clinical management of the disease.Methods: Among the 70 patients with nasal sinus malignant lymphoma,42 patients underwent radiotherapy and chemotherapy,and 28 patients received radiotherapy only.Most of the patients were administered CHOP as their chemotherapy regimen,and the others received B-CHOP.Those who received local radio-therapy were performed the linear accelerator irradiation,and the radiological dose was 40~60 Gy for 3~5 weeks.The patients' clinical symptoms,signs,imaging information,biochemistry,pathology,treatment and prognostic factors were analyzed.Results: Of the 70 patients,51 were male(72.9%) and 19 female(27.1%);56 patients were at stageⅠe and stage Ⅱe(80.0%),and 55 patients had single nasal lesion(78.6%).T cell type was the major pathological classification;the main manifestations were stuffy nose,runny nose,swelling,epistaxis,oral and eye symptoms and even complaints in the neck.40 patients survived for 5 years without suffering,and the disease-free survival rate(DFR) was 57.1%.In the 5-year DFR,30 patients received both radiotherapy and chemotherapy,and 10 patients received chemotherapy only,with a DFR rate of 71.4% and 35.7%,respectively;The difference was statistically significant(P<0.01).In the patients at stage Ⅰe,21 cases received both radiotherapy and chemotherapy survived for 5 years and 10 cases received only radiotherapy survived for 5 years,with a DFR rate of 87.5% and 55.6%,respectively.The difference was statistically significant(P<0.05).7 patients at stage Ⅱe who received radiotherapy and chemotherapy survived for 5 years,while only 2 patients at stage Ⅲe～Ⅳ survived;the difference was not statistically significant(P>0.05).No patients at stage Ⅱe or Ⅲe～Ⅳ survived for 5 years among those who had received radiotherapy only.Conclusions: The clinical staging and treatment methods are the main factors affecting the 5-year DFR.The CHOP combined with radiotherapy could make a better prognosis,and significantly improve the 5-year DFR in patients with malignant lymphoma of the nasal cavity and paranasal sinuses.