Preliminary study on the bacterial endotoxin test for compound lidocaine injection

Objective: To establish a bacterial endotoxin test for monitoring pyrogens in compound lidocaine injection.Methods: The bacterial endotoxin test procedure and guiding principle in Chinese Pharmacopoeia were used.Results: The test using limulus agent with a sensitivity of 0.5 Eu/m showed that the reaction was not interfered by compound lidocaine injection.Conclusions: Limulus bysate method can be used to monitor the pyrogens in compound lidocaine injection.