The significance of the expression of vascular endothelial growth factors and its receptor KDR in ovarian endometriosis

Objective: To investigate the expressions of vascular endothelial growth factor (VEGF) and its kinase insert domain receptor (KDR) in eutopic endometrium and ovarian ectopic endometrium and its surrounding ovarian tissue patients with ovarian endometriosis (OEM),and to explore their roles in the mechanism of development of OEM.Methods: Using immunohistochemical S-P technique,the expressions of VEGF and KDR were examined and analyzed in the tissue of ovarian ectopic endometrium (44 specimens),ovarian tissue surrounding ectopic endometrium (44 specimens) and eutopic endometrium (20 specimens) from 51 women patients with OEM (stage Ⅱ-Ⅲ) compared with their expressions in the control proliferative eutopic endometrium without endometriosis (18 specimens).Results: VEGF and KDR expressions were mainly located in the cytoplasm of gland epidermis in eutopic and ectopic endometrium.The positive rates of VEGF and KDR proteins in ovarian ectopic endometrium were 63.6% and 54.6%,respectively,while the positive rates in ovarian tissue surrounding ectopic endometrium were only 6.8%,15.9%,respectively.The positive rates of VEGF and KDR proteins in ovarian ectopic endometrium were both significantly higher than those in ovarian tissue surrounding ectopic endometrium (P=0.000 1 and P=0.008 4).And their synchronization expressions in ectopic endometrium were a positive correlation (P=0.000).The positive rates of VEGF and KDR proteins in eutopic endometrium with endometriosis were 80.0% and 75.0%,respectively,while the positive rates in eutopic endometrium without endometriosis were only 16.7% and 27.8%,respectively.The difference of VEGF and KDR in eutopic endometrium with endometriosis compared with that without endometriosis was significant (P<0.01).The expressions of them in ectopic and eutopic endometrium with endometriosis was similar and not statistical significant (P>0.05).Conclusions: The expressions of VEGF and KDR in ectopic endometrium tissue were both significantly higher than those in ovarian surrounding tissue.Therefore their synchronization expressions might be relative to angiogenesis in ovarianendometriosis.The expressions of VEGF and KDR in eutopic endometrium with endometriosis were significantly higher than those without endometriosis,and the expressions of them in ectopic and eutopic endometrium with endometriosis were similar,which supported the theory "determinant of uterine eutopic endometrium".