• 中国科技论文统计源期刊
  • 中国科技核心期刊
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  • 安徽省优秀科技期刊
WANG Yuan-yuan, CHEN Xiao-rong, LIU Tong, TANG Jie, XIE Chang-hao. Analysis of frequency and expression of programmed cell death-1 of CD4+CD25highTreg peripheral blood in systemic lupus erythematosus patients[J]. Journal of Bengbu Medical University, 2011, 36(11): 1184-1186.
Citation: WANG Yuan-yuan, CHEN Xiao-rong, LIU Tong, TANG Jie, XIE Chang-hao. Analysis of frequency and expression of programmed cell death-1 of CD4+CD25highTreg peripheral blood in systemic lupus erythematosus patients[J]. Journal of Bengbu Medical University, 2011, 36(11): 1184-1186.

Analysis of frequency and expression of programmed cell death-1 of CD4+CD25highTreg peripheral blood in systemic lupus erythematosus patients

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  • Received Date: July 19, 2011
  • Objective:To detect frequency of and programmed cell death-1(PD-1) expression of CD4+CD25highTreg peripheral blood of systemic lupus erythematosus(SLE) patients and to explore their roles in immune disorder of SLE. Methods:Flow cytometry(FCM) was used to determine the frequencies of peripheral blood CD4+CD25highTreg and CD4+CD25lowT cells and the PD-1 expression on these cells in SLE patients and healthy normal controls. Results:The frequency of CD4+CD25highTreg among CD4+Treg in peripheral blood of SLE patients group(0.63±0.31)% decreased significantly(P<0.01),compared with normal control group(2.07±0.74)%. The PD-1 expression on CD4+CD25highTreg in SLE group(24.99±18.65)% was obviously higher than that in normal control groups(6.97±1.92)% (P<0.05). There were also was no significant differences in both the frequency of CD4+CD25lowT cells and the PD-1 expression on these subset cells among two groups(P<0.05). Conclusions:Decreased number of CD4+CD25highTreg and upregulated expression of PD-1 on these Treg may play an important role in the pathogenesis of SLE.

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