Weekly docetaxel for treatment of advanced gastric cardia cancer in the elderly:a report of 28 cases

Objective:To observe the efficacy of weekly administration of domestic docetaxel on advanced cardia cancer in the elderly.Methods:Twenty-eight elderly patients with advanced cardia cancer receiving chemotherapy were treated with domestic docetaxel in the dose of 35 mg/m² on day 1,8 and 15 every 28 days.Evaluation was performed after two cycles,and the patients who did not respond went through another two cycles.Results:All the 28 cases were evaluated.CR was observed in 0 cases,PR in 10 cases,SD in 6 cases and PD in 12 cases,with a response rate of 35.7%.Clinical benefit was achieved in 57.1% of the cases.The common toxicities were Ⅰ to Ⅱ degree neutropenia,aneamia and shed-hair.Conclusions:Weekly domestic docetaxel shows good efficacy in treatment of advanced cardia cancer in the elderly,and the patients tolerate well.