Expression of STAT3 in breast cancer and its clinical significance

Objective: To investigate the expression of STAT3 in breast carcinoma and its relation with prognosis.Methods: The expression of STAT3 in 30 normal breast tissues and 76 cases of breast carcinoma was determined using immunohistochemical staining S-P method,and its association with prognosis was analyzed.Results: The positive expression of STAT3 in normal breast tissues(23.3%) was significantly lower than that in breast carcinoma(65.8%) (P<0.01).The expression of STAT3 in breast carcinoma was significantly associated with the surgical stage,differentiation and lymphatic invasion(P<0.05).Conclusions: High expression of STAT3 is associated with poor prognosis of breast carcinoma.