Study on the pharmacokinetics of ligustrazine phosphate dripping pills in healthy volunteers

Objective: To studdy the pharmacokinetics of ligustrazine phosphate dripping pills.Methods: Twenty healthy volunteers were given a single oral dose of 200 mg ligustrazine phosphate dripping pills.The serum concentrations of ligustrazine were determined by high performance liquid chromatogram (HPLC).The pharmacokinetic parameters were calculated with DAS2.0 practical pharmacokinetics program.Results: The main pharmacokinetics parameters of ligustrazine phosphate dripping pills were as follows:Ka was (0.151±0.144) min, T_max was (40.5±15.5) min, C_max was (1.7±0.3) μg/ml, t_1/2β was (67.7±3.2) min, CL/F was (0.017±0.004) L·min^-1·kg^-1, AUC 0-300 min was (181.5±40.3) μg·min^-1·ml^-1 and AUC_(0-∞) was (209.6±46.6) μg·min^-1·ml^-1, respectively.Conclusions: The preparation fits the two-compartment model best.