Study on microvessel density in non-small cell lung cancer

Objective: To study the relationship between microvessel density(MVD) of non-small cell lung cancer(NSCLC) tissues and the clinicopathological characteristics.Methods: The MVD was detected in 57 NSCLC tissues by immunohistochemical staining(S-P method) and the relationship of MVD to the clinical staging,pathologic typing and lymph node metastasis was studied.Results: MVD was closely related to the lymph node status,clinical staging and grade of cell differentiation of NSCLC(P<0.01),but not to the size of primary cancer,the histological classification and sex(P>0.05).Conclusions: MVD may play an important role in the oncogenesis,development and metastasis of NSCLC and is one of the reliable prognostic indicator of survials of NSCLC.