The establishment of animal model by ureaplasma urealyticum vertical transmission

Objective: To set up a vertical transmission animal model by genital infection with ureaplasma urealyticum(UU) during the course of cyesis.Methods: Kunming mice were infected by serotype 4 UU during the period of pregnancy through vagina,the vertical transmission from mother to filial generation was observed by UU culture and immumohistochemical staining test.Results: UU positive rates from the lung and spleen in the newborn mice by UU infection(3.5×10⁴ CCU/ml,5×10⁵ CCU/ml,and 10⁶ CCU/ml) were 0 and 0,2.7 and 1.4,and 74.4 and 30.3,respectively.Conclusions: The UU vertical transmission animal model during the course of cyesis was constructed successfaly through genital infection with UU in the pregnant mice.