Calcium gluconate combined with modified FOLFOX4 regimen for treatment of advanced gastric and colorectal carcinoma

Objective: To assess the neuroprotectant effect of Calcium gluconate combined with modified FOLFOX4 regimen on oxaliplatin-induced neurotoxicity.Methods: One hundred and ninety-six patients were randomly divided into two groups.Group A were administered modified FOLFOX4 regimen and Calcium gluconate.They were administered infusion of 5% Calcium gluconate(1 g) before and after oxaliplatin,and the regimen was repeated every two weeks.Group B received modified FOLFOX4 regimen only.Results: The response rate was 45.88%(39/85) and 46.85%(52/111) in group A and group B respectively(P>0.05),and the incidence of neurotoxicity was 49.41% and 65.77% in group A and group B respectively(P<0.05).Conclusions: Infusion of Calcium gluconate can effectively reduce the incidence of oxaliplatin-induced neurotoxicity without interfering the effect of modified FOLFOX4 regimen.