Relationship between the expression of pS2 and neu oncogene in breast carcinomas and metastases of drainage lymph nodes

Objective: To study the expression of pS2 and neu oncogene in female breast carcinomas and its significance.Methods: Immunohistochemistry SP method was used to detect the oncogene expression retrospectively in tissue blocks of 65 cases of breast cancer.Results: The positive expression of pS2 and neu are 50.8% and 46.2%,respectively,in 65 cases of breast cancer.The positive rates of neu oncogene in lymph node metastasis were markedly different from that without metastasis(P<0.01).Conclusions: The overexpression of neu oncogene correlates with lymph node metastasis intimately.Therefore,clinic investigation of the expression neu may be one of important reference indexes to predict prognosis in patients.