Effect of ¹³¹I therapy on differentiated thyroid carcinoma metastases

Objective: To assess the effect of iodine-131(¹³¹I) therapy on patients with differentiated thyroid carcinoma metastases.Methods: Forty-five patients with differentiated thyroid carcinoma metastases were treated with ¹³¹I,and the dose of ¹³¹I varied according to the site of metastasis(370×10⁷ to 740×10⁷) Bq.The therapy was repeated 2 to 8 times at an interval of 4 to 12 months.The efficacy was assessed 4-6 months later with ¹³¹I whole body scanning and serum level of thyroglobulin.Results: Of the 45 cases,15 were cured,26 improved and 4 had no response.Conclusions: The therapy of high doses of ¹³¹I is safe and effective for treatment of differentiated thyroid carcinoma metastases with little adverse side-effect.