Effect of dose of neostigmine on recovery from atracurium-induced neuromuscular blockade

Objective: To investigate the effect of dose of neostigmine administration on recovery from atracrium induced neuromuscular blockade.Methods: Thirty patients(ASA Ⅰ and Ⅱ) were divided into three groups(each ten),and received neostigmine 20 μg/kg,35 μg/kg and 50 μg/kg,respectively.Results: The speed of recovery from atracurium induced neuromuscular blockade with neostigmine 20 μg/kg was lower as compared with 35 μg/kg and 50 μg/kg,but the difference was not significant between with neostigmine 35 μg/kg and 50 μg/kg.Conclusions: Recovery from atracurium-induced neuromuscular blockade was accelerated when dose of neostigmine was increased from 20 μg/kg to 50 μg/kg,35 μg/kg is the optimal dose of neostigmine for reversal of atracurium induced neuromuscular blockade.