Clinical significance of plasma protein Z level in patients with taking orally warfarin

Objective: To observe the alteration of protein Z(PZ) in patients with taking orally warfarin.Research the reason of this alteration and the monitor function of the PZ in pauients with taking orally warfarin.Methods: Thirty patients with taking orally warfarin and 23 healthy adults as the control group,and detect the level of the plasma PZ and prothrombin time(PT),PT:INR.PZ was measured by ELISA and PT,PT:INR were measured by stago auto-analyor.Results: In taking orally warfarin group PZ levels was(240.87±192.72) ng/ml.It compared with health group's PZ level(1 812.6±347.16) ng/ml has dropped(P<0.001).Taking orally warfarin group's PT(24.18±4.52) s compared with health group's PT(12.67±0.42) s has raised(P<0.001).Taking orally warfarin group's PT:INR(2.448±0.63) compared with health group's PT:INR(0.943±0.04) has raised(P<0.001).Conclusions: PZ level of the patients who take orally warfarin is obrions drop.Fingdings shows that taking orally warfarin could make the PZ drop.The plasma protein Z level can be used as an indicator to monitor the amonnt of warfarin.