Comparison of CD31 and CD34 in showing microvessel density in non-small cell lung cancer

Objective: To study the difference between CD31 and CD34 in showing the microvessel density(MVD) of non-small lung cancer(NSCLC),and to investigate the relationship between MVD and clincopathological parameters.Methods: Elivision^TM plus immunohistochemical techinique was used to detect the expression of CD31 and CD34 in 57 cases of NSCLC.Results: The MVDs shown by CD31 and CD34 were(29.7±12.1) and(38.2±12.7) respectively,within a range of 10-61 and 19-76.The difference was significant(P<0.001),but the correlation was good(P<0.05).No significant difference between MVD and clinopathological parameters was observed(P>0.05).Conclusions: The endothelial cell of micro-vessels can be shown by both CD31 and CD34,but CD34 is better than CD31 and is more suitable for clinical application.There is no significant difference between MVD and clinopathological parameters including metastasis of lymph node.