• 中国科技论文统计源期刊
  • 中国科技核心期刊
  • 中国高校优秀期刊
  • 安徽省优秀科技期刊
YUE Xi-cheng, LI De-qun. Expression of stat-3 and survivin in breast carcinoma and its significance[J]. Journal of Bengbu Medical University, 2009, 34(7): 584-587.
Citation: YUE Xi-cheng, LI De-qun. Expression of stat-3 and survivin in breast carcinoma and its significance[J]. Journal of Bengbu Medical University, 2009, 34(7): 584-587.

Expression of stat-3 and survivin in breast carcinoma and its significance

More Information
  • Received Date: August 12, 2008
  • Objective: To investigate the significance of the expression of stat-3 and survivin in the genesis and development of breast carcinoma.Methods: Immunohistochemistry S-P was utilized to measure the expression of stat-3 and survivin protein in 51 breast carcinoma tissues and 25 adjacent noncarcerous tissues.Results: The expression of stat-3 protein was higher in breast carcinoma tissues than that in the adjacent noncarcerous tissues(P<0.001);the expression of stat-3 protein was higher in the positive lymph node group than in the negative lymph node group(P<0.05).It was not related to the patients' age,size of tumor,pathological grades,clinical stages,ER,PR or cerbB-2(P>0.05).The expression of survivin protein was higer in breast carcinoma tissues than in the adjacent noncarcerous tissues,and the difference was significant(P<0.001).The expression of survivin protein had no significant coorelation with the patients'age,size of tumor,pathological grades,clinical stages,lymph node metastasis,ER,PR or cerbB-2(P>0.05).Of the 35 cases with positive survivin protein expression,positive stat-3 protein was detected in 34 of them.The expression of survivin and stat-3 had positive correlation in breast carcinoma(P<0.05).Conclusions: stat-3 and survivin may play an important role in the carcinogensis and progression of breast carcinoma by inhibiting apoptosis.

Catalog

    Article views (2925) PDF downloads (32) Cited by()
    Turn off MathJax
    Article Contents

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return