Relationship between polymorphism of the human intestinal fatty acid binding protein gene and metabolic parameters of type 2 diabetic patients

Objective: To explore relationship between polymorphism of the human intestinal fatty acid binding protein gene and metabolic parameters of type 2 diabetic patients.Methods: One hundred and fourty Han nationality in Bengbu were screened for presence of codon 54 variation by PCR-RFLP assay,identified by the enzyme HhaⅠEighty patients with type 2 diabetes mellitus(T2DM) and sixty normal controls(NC).Results: The polymorphic restriction site was found in the FABP 2 identified by the enzyme HhaⅠin Han nationality of Bengbu(the freqencies of Ala54 and thr54 in Bengbu were 0.67and 0.33,respectively).The type 2 diabetes-mellitus(T2DM) subjects had higher HOMR-IR,FINS,FPG,TC,TG,LDL and lower ISI than NC subjects.The 2DM subjects with genotype Thr54(+) (Thr54 homozygotes and heterozygotes) had higher FPG、FINS、HOMR-IR、TG、LDL(P<0.01) and lower ISI(P<0.01) than those with genotype Thr(-) (Ala54 homozygotes).Conclusions: The polymorphy of FABP2 has been identified in the Han nationality in Bengbu.The genotype Thr54 homozygotes and heterozygotes of FABP2 gene seems to be associated with the insulin resistance of the type 2 diabetic patients.They also may be involved in the determination of lipoprotein profiles in the type 2 diabetic patients.