The mechanism exploration of vancomycin resistant Staphylococcus aureus

Objective: To study the drug resistance mechanism of Staphylococcus aureus (aureaus) to vancomycin. Methods: Vancomycin was applied in vitro to induce vancomycin resistant heterogeneity aureaus strains; then nuc gene(aureaus specificity gene) and vanA gene(vancomycin resistance gene) were detected by PCR. Results: Vancomycin resistant aureaus contained nuc gene,but no vanA gene. Conclusions: Vancomycin resistant aureaus contains no common vancomycin resistant gene,cell wall thickening is maybe one of the main mechanisms of aureaus to vancomycin resistance.