Detection of Dkk-1 in pancreatic carcinoma and its clinical significance

Forget MA,Turcotte S,Beauseigle D,et al.The Wnt pathway regulator DKK-1 is preferentially expressed in hormone-resistant breast tumours and in some common cancer types[J].British J Cancer,2007,96(4):646-653. [2] Yamabuki T,Takano A,Hayama S,et al.Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas[J].Cancer Res,2007,67(6):2517-2525. [3] Takahashi N,Fukushima T,Yorita K,et al.Dickkopf-1 is overexpressed in human pancreatic ductal adenocarcinoma cells and is involved in invasive growth[J].Int J Cancer,2010,126(7):1611-1620. [4] 余艳军，万晓桢，于彬，等.Dickkopf(DKK-l) 在肝癌组织及多种人肿瘤细胞系中的表达分析[J].肿瘤，2006，26(12)：1109-1112. [5] Grotewold L,Ruther U.The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death[J].EMBO J,2002,21(5):966-975. [6] Sato N,Yamabuki T,Takano A,et al.Wnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapy[J].Cancer Res,2010,70(13):5326-5336. [7] 周颖，李兆申，王东，等.Wnt/β-catenin信号通路和Dickkopf-1在胰腺癌中的研究进展[J].胃肠病学，2010，15(12)：752-754. [8] 章瑜，俞康.DKK-1基因沉默的人多发性骨髓瘤细胞培养上清对小鼠前成骨细胞成骨分化的影响[J].中国病理生理杂志，2013，29(6)：1129-1132. [9] 尚立群，王伟，李学昌，等.食管癌患者围术期血清热休克蛋白27,70,DKK-1及红细胞免疫黏附促进,抑制因子变化规律研究[J].中国医药导报，2012，9(19)：46-47. [10] 周颖，王东，李兆申，等.内镜超声引导下细针抽吸标本Dickkopf-1检测对胰腺癌的诊断价值[J].胃肠病学，2011，16(1)：7-10. [11] Levy C,Lymp J,Angulo P,et al.The value of serum CA 19-9 in predicting cholangiocarcinomas in patients with primary sclerosing cholangitis[J].Digest Dis Sci,2005,50(9):1734-1740. [12] 张美华，徐清芳，王莹，等.CEA,CA19-9,CA242,联合 CA50 检测对胰腺癌诊断的临床价值[J].中国实用医药，2013，8(22)：72-73.