• 中国科技论文统计源期刊
  • 中国科技核心期刊
  • 中国高校优秀期刊
  • 安徽省优秀科技期刊
WANG Qiang-wu, WANG Qi-zhi, LI Da-peng, ZHENG Hai-lun, SUN Yi-xue, ZHOU Lei, ZHU An-you, . Detection of Dkk-1 in pancreatic carcinoma and its clinical significance[J]. Journal of Bengbu Medical University, 2014, 38(6): 718-720,723.
Citation: WANG Qiang-wu, WANG Qi-zhi, LI Da-peng, ZHENG Hai-lun, SUN Yi-xue, ZHOU Lei, ZHU An-you, . Detection of Dkk-1 in pancreatic carcinoma and its clinical significance[J]. Journal of Bengbu Medical University, 2014, 38(6): 718-720,723.

Detection of Dkk-1 in pancreatic carcinoma and its clinical significance

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  • Received Date: November 21, 2013
  • Objective:To detect the expression of the Dickkopf-1(DKK-1) in pancreas space-occupying lesions and its value in the diagnosis and differential diagnosis of pancreatic cancer.Methods:Sixty-three paraffin specimens of pancreas space-occupying lesions were collected,the expressions of DKK-1 in pancreatic cancer tissue and pancreatitis tissue were detected using immunohistochemical method.The blood CA19-9 level was measured by automatic labeling immunoluminescence analyzer.The relationships between DKK-1 and clinically pathological characteristics of patients and blood CA19-9 were analyzed.Results:The positive expression rate of DKK-1 in pancreatic cancer tissue(68.2%) was significantly higher than that in benign pancreatic lesions(5.3%)(PPPConclusions:The expression of DKK-1 in pancreatic cancer tissue is significantly higher than that in benign pancreatic lesion,which plays an important role in the formation and growth of pancreatic tumor.The detection of DKK-1 is helpful to the diagnosis and prognosis assessment of pancreatic cancer.
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