The effect of ketamine on haemodynamics in global cerebral ischemia reperfusion injury of rabbits

Objective:To investigate the effects of ketamine on haemodynamics in global cerebral ischemia reperfusion injury of rabbits.Methods:Fifteen adult healthy New Zealand white rabbits were randomly divided into control group(group A),model group(group B) and ketamine group(group C).The global cerebral ischemia reperfusion model of group B and C was established by two-vessel occlusion combined with femoral arterial bloodletting.The rabbits in group C were injected with ketamine by femoral vein after nipping bilateral common carotid arteries,and electroencephalogram(EEG),electrocardiogram(ECG),mean arterial blood pressure(MAP) and heart rate(HR) were monitored during operation.Results:Compared with group A,the HR of group B and C sped significantly up at 30 minutes after ischemia(P0.01),and the HR of group B was significantly lower than that in group A(P0.01) at 30 min after reperfusion.The MAP of group B were significantly lower than that in group A and C(P0.01) at 30 min after ischemia,and began to rise at 30 mins after reperfusion and was still less than basic value(P0.01).The EEG of group C was significantly higher than that in group A and B at 30 mins after ischemia and reperfusion(P0.01).The HR of group C was significantly higher than that in group B at 30 min after ischemia(P0.01),and HR at 30 mins after reperfusion of group C were significantly higher than that in group B(P0.01).Conclusions:Ketamine can maintain the haemodynamic stability of rabbit global cerebral ischemia reperfusion injury,which can effectively alleviate and reduce brain injury caused by ischemia reperfusion.