Clinical significance and expressions of hypoxia-induced factor-1and carbonic anhydrase IX in cervical squamous cell carcinoma

Objective:To explore the clinical significance and expressions of hypoxia-induced factor-1(HIF-1) and carbonic anhydrase Ⅸ(CAⅨ) in cervical squamous cell carcinoma(SCC).Methods:The expression characteristics and correlations of HIF-1 and CAⅨ in normal cervical tissues of 30 cases,cervical intraepithelial neoplasia(CIN) of 55 cases and SCC tissues of 80 cases were detected by immunohistochemistry of EliVision Plus/HRP.Results:The positive expression rates of HIF-1 in normal cervical tissues,CIN tissues and SCC tissues were increased gradually,whose were 0.00%,43.64% and 76.25%,respectively,and their differences were statistical significant(P0.01).The positive expression rates of CAⅨ in normal cervical tissues,CIN tissues and SCC tissues were increased gradually,whose were 0.00%,40.00% and 66.25%,respectively,and their differences were statistical significant(P0.01).The expression rates of HIF-1 and CAⅨ in poorly differentiated SCC were significantly higher than those in well or moderated differentiated SCC(P0.05).The expression rates of HIF-1 and CAⅨ in SCC with lymph node metastasis were significantly higher than those in SCC without lymph node metastasis(P0.05).The HIF-1 expression rates in SCC of clinical stage Ⅱ were significantly higher than those in clinical stage Ⅰ(P0.05).The expression of HIF-1 was significantly related to the CAⅨ expression in SCC(P0.05).Conclusions:HIF-1 and CAⅨ play an important role in the occurrence and development of SCC.The high expression and postive correlations of HIF-1 and CAⅨ in cervical SCC suggest the feasibility of the targeted molecular therapy based on the pathway induced by hypoxia factor for treatment of SCC.