The clinical significance of the serum levels of vascular endothelial growth factor and carbohydrate antigen 199 in patients with gastric cancer before and after chemotherapy

Objective:To investigate the significances of the serum level changes of vascular endothelial growth factor(VEGF) and carbohydrate antigen 199(CA199) in patients with gastric cancer before and after chemotherapy.Methods:The serum levels of VEGF and CA199 of 40 cases with gastric cancer were measured by ELISA,and which were compared with those in forty healthy people.Results:The serum levels of VEGF and CA199 in gastric carcinoma patients were significantly higher than those in the healthy people before chemotherapy(P0.01),but the serum levels in complete remission and partial remission patients in 8 weeks post-chemotherapy were significantly lower than those in pre-chemotherapy(P0.01).The VEGF levels in the stable treatment patients had no statistical significance(P0.05),and the CA199 levels were lower than that of before chemotherapy(P0.01).The serum levels of VEGF and CA199 in the progress group were higher than those of before treatment and existed the positive correlation(P0.01).Conclusions:The serum levels of VEGF and CA199 in patients with gastric cancer are important parameters for early diagnosis and evaluating treatment effects.