Effects of high glucose concentrations on the auto-rhythmicity of the smooth muscle of duodenum of rabbits

Objective: To observe the effects of high concentration of glucose on the auto-rhythmicity of the smooth muscle of rabbit duodenum.Methods: Duodenum of rabbits were isolated and put into normal Tyrode solutions.Tyrode solutions coutaining high glucose(9.7 mmol/L and 11.1 mmol/L),and then the curve of contraction was recorded.Results: The contraction amplitude of the duodenum in Tyrode solution containing glucose concentrations 9.7 mmol/L was distinctly inhibited at 10 min(P<0.05),while that in Tyrode solution containing glucose of 11.1 mmol/L was distictly inhibited at 20 min(P<0.05);and then the contraction rose gradually.Conclusions: High concentration of glucose may make the contraction of duodenum inhibited.When the glucose concentrations in Tyrode solution increased,the time when the contraction of the duodenum was inhibited was prolonged.