The effect of triamcinolone acetonide on nuclear factor-KB andvascular endothelial growth factor expression in retinal neovascularization in rats

To investigate the effect of triamoinolone acetonide on the nuclear factorcB(NFcB)and vascular endothelialgrowth factor(VEGF)expression in retinal neovascularization of rats. Methods:Forty SD 7 days old rats were selected 10 rats were innormal environment as control. Models of retinal neovascularization of 30 rats were established using oxygennduced which weredivided into other three groups 10 rats cavum vitreum were injected with 1 p,1(0. 04 mg)of triamoinolone acetonide as hyperoxia. ombined with medication group 10 rats cavum vitreum were injected with balanced saltsolution(BSS)as hyperoxia combined with BSSgroup and the left 10 rats acted as hyperoxia control group. HE staining the expression of NFcB and VEGF using immunohistochemicalmethod in the retina of 20 eyes of each group were explored. Results: The number of neovascular nuclei of the rat retina of hyperoxia. ombined with medication group were significantly less than that of hyperoxia control group and hyperoxia combined with BSS group(p0. O1). However the expression of NFcB and VEGF were significantly lower(p0. OS). With the high level of expression ofVEGF the expression of NFcB in the retina was also rising. Conclusions:Triamcinolone plays a role in inhibiting retinalneovascularization and the expression of NFycB and VEGFand the expression of NFycB and VEGF in the retina showes positive correlation