Expression and significance of eIF4E and CyclinD1 in endometrial hyperplasia and endometrial carcinoma

SUN Le-shui; GE Xia

Journal of Bengbu Medical University > 2013 > 37(3): 258-262.

SUN Le-shui, GE Xia. Expression and significance of eIF4E and CyclinD1 in endometrial hyperplasia and endometrial carcinoma[J]. Journal of Bengbu Medical University, 2013, 37(3): 258-262.

Citation:

SUN Le-shui, GE Xia. Expression and significance of eIF4E and CyclinD1 in endometrial hyperplasia and endometrial carcinoma[J]. Journal of Bengbu Medical University, 2013, 37(3): 258-262.

Citation:

SUN Le-shui, GE Xia. Expression and significance of eIF4E and CyclinD1 in endometrial hyperplasia and endometrial carcinoma[J]. Journal of Bengbu Medical University, 2013, 37(3): 258-262.

Expression and significance of eIF4E and CyclinD1 in endometrial hyperplasia and endometrial carcinoma

SUN Le-shui¹,
GE Xia^2, ,

1.
1. Department of Pathology,The First Affliated Hospital of Bengbu Medical College,Bengbu Anhui 233004;
2.
2. Department of Pathology,Bengbu Medical College,Bengbu Anhui 233030,China

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Received Date: February 28, 2012

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Objective:To study the expression and clinical significance of eIF4E and CyclinD1 in endometrial hyperplasia and endometrial carcinoma.Methods:The expressions of eIF4E and CyclinD1 in 40 cases of simple hyperplasia,40 cases of complex hyperplasia(25 cases of atypical hyperplasia),65 cases of endometrial carcinoma and 15 cases of normal proliferative endometrium were detected by means of immunohistochemical EliVision,the related pathological parameters were analyzed.Results:The positive expression of eIF4E in normal proliferative endometrium,simple endometrial hyperplasia,complex endometrial hyperplasia,atypical hyperplasia and endometriod adenocarcinoma was 53.33%,72.50%,80.00%,84.00% and 90.77%,respectively;while the positive expression of CyclinD1 was 6.67%,52.50%,70.33%,80.00% and 81.54%,respectively.The expression of eIF4E was only significantly different between the endometrial carcinoma and the normal proliferative endometrium(P0.01);the expression of CyclinD1 in endometriod adenocarcinoma,atypical hyperplasia and complex endometrial hyperplasia was significantly different from that in normal proliferative endometrium.The positive expression of eIF4E and CyclinD1 in endometriod adenocarcinoma was not obviously related to the TNM stage,pathological grade or lymph node metastasis(P0.05).Statistical analysis showed that there was a positive correlation between eIF4E and CyclinD1 expression in endometriod adenocarcinoma(P0.05).Conclusions:EIF4E and CyclinD1 are both over-expressed in endometrial carcinoma,and the synergy of them may contribute to the development of endometrial carcinoma.
- endometrial neoplasms,
- eIF4E,
- CyclinD1,
- endometrial prolilerative lesion,
- immunohistochemistry

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[1]	[2] Shantz LM, Pegg AL;. Over production of omithine decarboxylasecaused by relief of translational repression is associated withneoplastic transformation[J].Cancer Res,1994,54 (9):2313-2316.
[1]	Altucci L, Arap W, Schaver IE et al. Cyclins and cancer: cyclinDand CDK inhibitors come to age[J].Oncogene, 1996, 12(10):2315.
[2]	[3] De Benedetti A, Harris AL. eIF4E expression in tumors: itspossible rolein progression of malignancies[J].Int,J Biochem CellBiol,1999,31 (1):59-72.
[3]	[4] De BenedettiA, Graff JR. eIF4E expression and its role inmalignancies and metastases.Oncogene, 2004, 23(18):3189-3199.
[4]	[5] Rosenwald IB.The role of translation in neoplastic transformationfrom a pathologist's point of view[J].Oncogene,2004,23 (18):3230-3247.
[5]	[6] Nathan CA, Leskov IL, Lin M, et al. COX2 expression in dysplasiaof the head and neck:correlation with eIF4E[J].Cancer,2001,92(7):1888-1895.
[6]	[7] Berkel HJ, Turbat Herrera EA, Shi R, et al. Expression of thetranslation initiation factor eIF4E in the poly-cancer sequence inthe colon[J].Cancer Epidemiol Biomarkers Prev, 2001，10 (6):663-666.
[7]	[8] Gu X,,Jones L, Lowery Norberg M, et al. Expression of eukaryoticinitiation factor 4E in astrocvtic tumors[J].Appl lmmunohistochemMol Morphol, 2005,13 (2):178-183.
[8]	[9] Chen CN, Hsieh FJ, Cheng YM, et al. Expression of eukaryoticinitiation factor 4E in gastric adenocarcinoma and its associationwith clinical outcome[J].J Surg Onco1,2004,86 (1):22-27.
[9]	[10] Zhou S, Wang GP, Liu C, et al. Eukaryotic initiation factor 4E(eIF4E) and angiogenesis: prognostic markers for breast cancer[J].BMC Cancer,2006,6:231.
[10]	[11] Zhou,JX,Niehans GA,SharA,et al. Mechanisms of Gl checkpointlossin rescted early stage non-small cell lung cancer[J].Lung Cancer,2001,32(1):27-38.
[11]	[12] Moghaddam SJ, Haghighi EN, Samiee S, et al. Immunohistochemicalanalysis of p53, cyclinDl, RB1, c-fos and N-ras gene expression inhepatocellular carcinoma in Iran[J].World,J Gastro enterol, 2007，13 (4):588-593.
[12]	[13] Rose SL, Buller RL,. The role of p53 mutation in BRCA1- associated ovarian cancer[J].Minerva Ginecol, 2002, 54 (3): 201-209.
[13]	[14] Wang C,Li Z,Fu M,et al. Signal transduction mediated by cyclinDl: from genes to cell proliferation: a molecular target with therapeutic potential[J].Cancer Treat Res, 2004,119:217-237.
[14]	[15] Ivan Topisirovic ML, Guzman MJ, McConnell JD, et al. Aberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis[J].Mol Cell Bio1,2003,23 (24):8992-9002.
[15]	[16] T'suda H, Yamamoto K, Inoue T, et al. The role of p16-cyclind/ CDK-pRb pathway in the tumorigenesis of endometrioid-type endometrial carcinoma[J].Br J Cancer, 2000, 82 (3):675-682.

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