Comparison of HBV-M and HBV-DNA detection in HBV infectors in the North of Anhui

Objective:To compare the detection results of HBV-M and HBV-DNA.Methods:All 388 HBV patients were detected for the HBV-M by ELISA and HBV-DNA by FQ-PCR.Results:The positive rate of HBV-DNA in the group of HBsAg(+)/HBeAg(+)/HBcAb(+) was 91.25%,and the majority of the virus replication was 107 IU/ml;while the majority of the virus replication in the group of HBsAg(+)/HBeAb(+)/ HBcAb(+) was 103 IU/ml.The positive rate of HBV-DNA in the group of HBsAgAb(+)/HBeAg(+)/HBc(+) was higher than that in the group of HBsAg(+)/HBeAb(+)/HBcAb(+)(P0.05).The positive rate of HBV-DNA in the group of HBsAg(+)/HBeAg()/ HBc(+)Ab was 66.67%.The majority of the virus replication was 105 IU/ml and 106 IU/ml in patients with positive HBsAg(+)/HBeAg(+)/HBc(-)Ab.The positive rate of HBV-DNA in the group of HBsAg(+)/HBeAg(-)/HBcAb(+) was 30.77%.Conclusions:Patients with HBeAg(+) have the highest replication level in all the groups,which is closely associated with HBV-DNA.Virus replication in patients with HBeAb(+) and HBcAb(+) does not stop completely,but obviously decreases.Combination detection of HBV-M and HBV-DNA may display the immune status and virus replication level of patients with hepatitis B,which would provide experimental basis for clinical monitoring and drug administration.