Spatially genetic structure analysis of FGA and D5S818 loci in Chinese nation

Objective:To analyze the spatially genetic structure of FGA and D5S818 loci of Autosome in 87 Chinese and provide the molecular biology basis for exploring Chinese origin，migration，archaeology and ethnic diversity． Methods:Aggregative indicators were obtained from gene frequency matrix and spatially genetic structure of two short tandem repeat(STR) loci were investigated under visualization by principle component analysis and spatial data analysis of geographical information system． Results:The spatially genetic structure of FGA and D5S818 loci in Chinese could be divided into four large areas，which showed increasing trend from southeastern to northwestern and southwestern area． Conclusions:The spatially genetic structures of two STR loci have evidently genetic variability gradient in different region and crowd．