Detection of the coagulation function and prethrombosis state in patients with pregnancy-induced hypertension and its clinical significance

Objective: To study the changes and diagnostic value of coagulation function and relative variables of pretherombosis state in patients with pregnancy-induced hyertension(PIH).Methods: The prothrombin time(PT),activated partial prothrombin time(APTT),fibrinogen(Fbg),vWF,GMP-140,TAT,and were examined in 30 normal late-pregnancy women,30 non-pregnancy women and 40 patients with PIH.Results: In the normal late-pregnancy women and patients with PIH,the levels of PT was obviously lower(P<0.01),while the level of APTT had no significant change(P>0.05) compared with the non-pregnant women;the level of vWF,GMP-140 and TAT were obviously higher in PIH women(P<0.01)than in the non-pregnant and late-pregnant women;some variables,including Fbg and D-dimer were greatly higher in patients with PIH than in the non-pregnant women(P<0.01);further more,these changes became more apparent with the progression of the disease.Conclusions: The normal late-pregnant women and the PIH women are in the hypercoagulation and prethrombotic state.Antenatal examination of coagulation function and variables of prethrombosis state are important for the prevention and treatment of PIH.