Effect of sevoflurane preconditioning on hemodynamics and QT dispersion following carbon dioxide pneumoperitoneum in hypertension patients

Objective:To investigate the effect of sevoflurane preconditioning on QT dispersion(QTd) and hemodynamical changes following carbon dioxide(CO2) pneumoperitoneum in hypertension patients.Methods:Sixty hypertension patients who received laparoscopic cholecystectomy were divided into sevoflurane pretreatment group(30 cases) and control group(30 cases) randomly.The QTd values,mean arterial pressure(MAP) and heart rate(HR) were recorded in pre-induction(T0),before pneumoperitoneum(T1),and immediately(T2),at 5 min(T3),at 10 min(T4) after pneumoperitoneum.Results:In pretreatment group,MAP,HR and QTd value at T2,T3 and T4 were lower than those in control group(P0.05 to P0.01).Conclusions:Sevoflurane preconditioning can shorten QTd value and stabilize hemodynamical changes after CO2 pneumoperitoneum in hypertension patients.