Expression and clinical significance of PTEN in squamous cell carcinoma of the eyelid conjunctiva

Objective:To investigate the expression lack and effects of PTEN in squamous cell carcinoma of the eyelid conjunctiva(SCC).Methods:The expression of PTEN of 34 patients with squamous cell carcinoma of the eyelid conjunctiva and adjacent tissue of 10 patients were detected and statistically analysed through EliVision immunohistochemical method.Results:The positive expression rate of PTEN protein was 23.53% in squamous cell carcinoma of the eyelid conjunctiva,which were significantly less than that of adjacent tissue(100.00%)(P0.01).The 34.78% and 0.00% expression of PTEN in a well-differentiated and poorly differentiated SCC were detected,and the difference had statistically significant(P=0.034).Conclusions:The expression lack and low expression of squamous cell carcinoma of the eyelid conjunctiva may have a certain relation with the occurrence and development of tumor.