Research on immunity response about Taenia solium oncosphere TSO45-4B antigens FnⅢ structure domain linear B cells epitope peptides

Objective: To observe the humoral immune response induced by Taenia solium oncosphere TSO45-4B antigens FnⅢ structure domain linear B cells epitope peptides in mice.Methods: The two predicted B cell epitope peptides of TSO45-4B Fn Ⅲ structure domain conjugated with carrier protein of keyhole limpet hemocyanin were synthesized and used to immunize mice.The mice specific serum antibody titer to the epitope peptides synthesized was tested by ELISA.Results: The specific antibody to one of the predicted epitope peptides synthesized was found in mice serum,and the titer was 1∶ 1 280.Conclusions: One of the two predicted linear B cell epitope peptides of TSO45-4B FnⅢ structure domain can induce the humoral immune response in mice.