• 中国科技论文统计源期刊
  • 中国科技核心期刊
  • 中国高校优秀期刊
  • 安徽省优秀科技期刊
ZHOU Hai-yan, SHI Jian-hua, HUANG Yong-qi, CHEN Yan. The correlation between FABP2 polymorphism and the metabolism of type 2 diabetic patients and their non-diabetic first-degree relatives[J]. Journal of Bengbu Medical University, 2013, 37(5): 545-549.
Citation: ZHOU Hai-yan, SHI Jian-hua, HUANG Yong-qi, CHEN Yan. The correlation between FABP2 polymorphism and the metabolism of type 2 diabetic patients and their non-diabetic first-degree relatives[J]. Journal of Bengbu Medical University, 2013, 37(5): 545-549.

The correlation between FABP2 polymorphism and the metabolism of type 2 diabetic patients and their non-diabetic first-degree relatives

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  • Received Date: July 11, 2012
  • Objective: To explore the correlation between human intestinal fatty acid binding protein 2(FABP2) polymorphism and the metabolism of type 2 diabetic patients and their non-diabetic first-degree relatives.Methods: Two hundred and twenty-four patients with type 2 diabetes mellitus(T2DM) and their 84 non-diabetic first degree relatives(NDR),60 healthy person were divided into the T2DM,NDR and NC group,respectively.The restricted fragment length polymorphisms of Hha Ⅰ enzyme site in codon 54 of the intestinal FABP gene of three groups were analysed by PCR.Results: The polymorphic sites of FABP2 HhaⅠincluding Ala54Ala and Ala54Thr of FABP2 and Thr54Thr polymorphism fragment were found in three groups.The allele freqencies of Ala54 and thr54 were 0.67 and 0.33,respectively.Compared with NC group,the insulin resistance(IR) index,fasting insulin,and the levels of triglyceride(TG),total cholesterol(TC) and low density lipoprotein(LDL) increased significantly(P 0.01),the insulin sensitivity index and the level of high density lipoprotein(HDL) decreased significantly in T2DM group(P 0.01).Compared with patients with FABP2 Thr(-) genotype of T2DM group,the FINS,IR index,and the levels of fasting blood glucose(FBG),TG and LDL increased significantly(P 0.01),the insulin sensitivity index and the level of HDL decreased significantly in patients with FABP2 Thr(+) genotype(FABP2 Ala54Ala,Ala54Thr and Thr54Thr) of T2DM group(P 0.01).Compared to patients with FABP2 Thr(-) genotype of NDR group,the IR index and the level of TG increased significantly(P 0.01 and P 0.05),the insulin sensitivity index decreased significantly in patients with FABP2 Thr(+) genotype of T2DM group(P 0.01).Conclusions: The Han has FABP2 polymorphism in Bengbu.The IR and abnormal lipid metabolism exist in T2DM and NDR group.The FABP2 Thr(+) genotypes in T2DM and NDR groups are related to IR,which is one factor of abnormal lipid metabolism.
  • [1]
    [2] 马晓静,贾伟平,胡承,等.2 型糖尿病家系遗传特征的初步分析[J].中华医学杂志, 2008,88( 36):2541-2543.
    [1]
    Yang W,Lu J,Weng J, et al.Prevalence of diabetes among men and women in China[J].N Engl J Med,2010,62 ( 12 ):1090-1101.
    [2]
    [3] Crosasso P,Ceruti M,Brusa P.Preparation,characterization and properties of sterically stabilized paclitaxel-containing liposomes[J].J Control Release,2000,63( 1 /2):19-30.
    [3]
    [4] Utzschneider KM,van de Lagemaat A,Faulenbach MV,et al.Insulin resistance is the best predictor of the metabolic syndrome in subjects with a first-degree relative with type 2 diabetes[J].Obesity,2010,18( 9):1781-1787.
    [4]
    [5] Kusminski CM,Scherer PE.The road from discovery to clinic: adiponectin as abiomarker of metabolic status[J].Clin PharmacolTher, 2009,86( 6):592-595.
    [5]
    [6] Chen BH,Song Y,Ding EL,et al.Circulating levels of resistin and risk of type 2 diabetes in men and women: results from twoprospective cohorts[J].Diabetes Care,2009, 32( 2):329-334.
    [6]
    [7] Baier LJ,Bogardus C,Sacchettini JC.A polymorphismin the human intestinal fatty acid binding protein alters fatty acid transport across Caco-2 cells [J].J Biol Chem,1996,271( 8):10892-10896.
    [7]
    [8] Bu L,Salto LM,De Leon KJ, et al.Polymorphisms in fatty acid binding protein 5 show association with type 2 diabetes[J].Diabetes Res Clin Pract, 2011,92( 1):82-91.
    [8]
    [9] Stan S,Lambert M,Delvin E, et al.Intestinal fatty acid binding protein and microsomal trigly- ceride transfer protein polymorphisms in French-Canadian youth[J].J Lipid Res,2005,46( 2):320-327.
    [9]
    [10] Vimaleswaran KS,Radha V,Mohan V.Thr54 allele carriers of the Ala54Thr variant of FABP2 gene have associations with metabolic syndrome and hypertriglyceridemia in urban South Indians[J].Metabolism,2006, 55( 9):1222-1226.
    [10]
    [11] Albala C,Villarroel A,Santos JL,et al.FABP2 Ala54Thr polymorphism and diabetes in Chilean elders[J].Diabetes Res Clin Pract,2007,77( 2):245-250.
    [11]
    [12] Elbein SC,Hasstedt SJ,Wegner K, et al.Heritability of pancreatic beta-cell funvtion among nondiabetic members of Caucasian familial type 2 diabetic kindreds[J].J Clin Endocrinol Metab,1999, 84( 4):1398-1403.
    [12]
    [13] Chiu KC,Chuang LM,Chu A,et al.Fatty acid binding protein 2 and insulin resistance[J].European J Clin Invest,2001,31(6):521-527.
    [13]
    [14] Zhang F,Lucke C,Baier LJ,et al.Solution structure of human intestinal fatty acid binding protein with a naturally occurring single amino acid substitution( A54T ) that is associated with altered lipid metabolism[J].Biochemistry,2003,42 ( 24 ):7339-7347.
    [14]
    [15] Montoudis A,Seidman E,Boudreau F,et al.Intestinal fatty acid binding protein regulates mito chondrion -oxidation and cholesterol uptake[J].J Lipid Res,2008,49(5):961-972.
    [15]
    [16] Auinger A,Helwig U,Rubin D,et al.Human intestinal fatty acid binding protein 2 expression is associated with fat intake and polymorphisms[J].J Nutr,2010,140(8):1411-1417.

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