The correlation between FABP2 polymorphism and the metabolism of type 2 diabetic patients and their non-diabetic first-degree relatives

Objective: To explore the correlation between human intestinal fatty acid binding protein 2(FABP2) polymorphism and the metabolism of type 2 diabetic patients and their non-diabetic first-degree relatives.Methods: Two hundred and twenty-four patients with type 2 diabetes mellitus(T2DM) and their 84 non-diabetic first degree relatives(NDR),60 healthy person were divided into the T2DM,NDR and NC group,respectively.The restricted fragment length polymorphisms of Hha Ⅰ enzyme site in codon 54 of the intestinal FABP gene of three groups were analysed by PCR.Results: The polymorphic sites of FABP2 HhaⅠincluding Ala54Ala and Ala54Thr of FABP2 and Thr54Thr polymorphism fragment were found in three groups.The allele freqencies of Ala54 and thr54 were 0.67 and 0.33,respectively.Compared with NC group,the insulin resistance(IR) index,fasting insulin,and the levels of triglyceride(TG),total cholesterol(TC) and low density lipoprotein(LDL) increased significantly(P 0.01),the insulin sensitivity index and the level of high density lipoprotein(HDL) decreased significantly in T2DM group(P 0.01).Compared with patients with FABP2 Thr(-) genotype of T2DM group,the FINS,IR index,and the levels of fasting blood glucose(FBG),TG and LDL increased significantly(P 0.01),the insulin sensitivity index and the level of HDL decreased significantly in patients with FABP2 Thr(+) genotype(FABP2 Ala54Ala,Ala54Thr and Thr54Thr) of T2DM group(P 0.01).Compared to patients with FABP2 Thr(-) genotype of NDR group,the IR index and the level of TG increased significantly(P 0.01 and P 0.05),the insulin sensitivity index decreased significantly in patients with FABP2 Thr(+) genotype of T2DM group(P 0.01).Conclusions: The Han has FABP2 polymorphism in Bengbu.The IR and abnormal lipid metabolism exist in T2DM and NDR group.The FABP2 Thr(+) genotypes in T2DM and NDR groups are related to IR,which is one factor of abnormal lipid metabolism.