The efficacy risperidone oral solution combined with sodium valproate sustained release tablets in treatment of senile mania

Objective:To observe the clinical curative effect and safety of risperidone oral solution combined with sodium valproate sustained release tablets in the treatment of senile mania.Methods:Seventy cases of senile mania were adopted randomly into two groups,the patients in the observation group were treated with risperidone oral solution combined with sodium valproate sustained release tablets,others in the control group were treated with sodium valproate sustained release tablets only,all patients were observed for 6 weeks.Mania Rating Scale(BRMS)was used to evaluate the curative effect,and treatment emergent symptom scale(TESS) was used to evaluate adverse reactions,all results were compared and analyzed.Results:The socres of BRMS in the two groups were not different before treatment(P0.05).In observation group,BRMS scores at every weekend were decreased,which were better than in control group significantly(P0.01),the total efficiency of 6 weeks was 88.57% in observation group,and 80.00% in control group,there was no statistical difference(P0.05).Conclusions:In the treatment of senile mania,risperidone oral solution combined with sodium valproate sustained release tablets has a fast onset of action and a good efficacy,fewer adverse reaction.Drug compliance isgood,and suitable for aged person.