Short-term curative effect of neoadjuvant chemotherapy on locally adanced cervical cancer:a report of 25 cases

Objective:To investigate the effect of preoperative neoadjuvant chemotherapy with PT on locally advanced cervical cell cancer.Methods:Fifty cases of locally advanced cervical cell cancer in stageⅠB-ⅡA were retrospectively analyzed.Twenty-five cases were managed preoperatively by regiment of PT chemotherapy(paclitaxel+carboplatin) for 2 cycles and followed by the therapeutic value.The radical surgery was conducted after two weeks of the chemotherapy.The other 25 cases were only managed by radical surgery.Results:Preoperative neoadjuvent chemotherapy with PT significantly decreased the primary tumor sizes(P0.05).The total effective rate was 76.00%.Chemotherapy adverse reaction in NACT group was light.Operation time and perioperative bleeding in NACT group was lower than those in the control group(P0.05 to P0.01).No significant difference existed in postoperative recovery time of bladder function and gastrointestinal function between two groups(P0.05).High-risk pathological factor rate in NACT group and control group was not statistically significant(P0.05).Conclusions:Preoperative chemotherapy with PT in locally adanced cervical cancer can reduce primary tumor sizes,decrease postoperative infiltration around uterine,reduce lymph node metastasis,and reduce the postoperative complications and recurrence.It is worthy of clinical application.