The Survivin expression and its significance in cervical cancer and precancerous lesions

Objective: To investigate the application value of Survivin expression in the diagnosis of cervical cancer and precancerous lesions by in situ hybridization.Methods: The Survivin expressions in 45 tissue samples of cervical cancer(observation group),45 tissue samples of cervical intraepithelial neoplasia(control group 1) and 45 normal cervical tissue samples(control group 2) were detected by in situ hybridization.Results: The positive rates of Survivin expression in control group 2,control 1 group and observation group were 2.2%,48.9% and 84.4%,respectively,the differences of which were statistically significant(P<0.01).The differences of positive rate of Survivin expression in the patients with stageⅠ,Ⅱ and Ⅲ cervical cancer,high,moderate and low differentiation cervical cancer and cervical cancer complicated with and without lymph node metastasis were not statistically significant(P>0.05).Conclusions: Survivin plays certain role in the occurrence and development of cervical cancer and precancerous lesions,which can be used as a sign of poor prognosis.