Short-term efficacy of paclitxel plus cisplatin combined with adiotherapy on advanced cervix cancer

Objective: To observe the short-term efficacy and toxicity of paclitxel plus cisplatin combined with radiotherapy in treatment of advanced cervix cancer.Methods: Thirty-six patients with advanced cervix cancer (Ⅱ b-Ⅲ b ) received concurrent chemoradiotherapy.The external irradiation dose of radiotherapy was 2Gy per time，5d /W，with a total dose of 50Gy; 192 Ir high-dose-rate afterloading unit was adopted for branchytherapy one week after external radiotherapy， at a dose of 7 Gy per time in A point for 6 times.Paclitxel (135mg /m2 ，d1 ) and cisplatin (25mg /m2 ，d1- d3 ) were given every 3- 4 weeks for two cycles concurrently with radiotherapy.The short effectiveness and toxic reaction were observed in these patients.Results: Of the 36 cases， complete response was observed in 27 cases，partial response in 7 cases and two cases presented certain progress.The overall response rate was 94.4%.There was no statistical significance in differences of patients' pathologic patterns and clinical stages(P0.05) .The main toxicities were leucopenia and radiation rectal reaction.Conclusions: The short term efficacy of concurrent chemoradiotherapy with paclitxel and cisplatin is relatively good on patients with advanced cervical cancer， and the side effects are well tolerated.