The curative effect and immune function influence of oxaliplatin combined with capecitabine in the treatment of patients with gastric cancer

ObjectiveTo investigate the clinical curative effects， safety and immune function influence of oxaliplatin combined with capecitabine in the treatment of patients with gastric cancer. Methods: Fifty-two patients with gastric cancer were randomly divided into treatment group and control group( 26 cases each group) .The control group were treated with oxaliplatin combined with 5-fluorouracil and calcium folinate.the treatment group were treated with oxaliplatin combined with capecitabine.The curative effects， levels of T cell subgroup and incidence of adverse reactions of two groups were compared.Results: The total effective rates of the control group and treatment group were 61.54% and 65.38%， the difference of which had no statistical significance( P 0.05) .Compared with before chemotherapy， the levels of CD3 + and CD4 + of two groups decreased after chemotherapy and 2 days in chemotherapy( P 0.05 to P 0.01) .The differences of the levels of CD3 + after chemotherapy and CD4 + after chemotherapy and 2 days in chemotherapy in two groups had statistical significance( P 0.05 to P 0.01) .The levels of CD8 + in two groups did not obviously change before and after chemotherapy， the difference of which had no statistical significance ( P 0.05) .The incidence of nausea and vomiting，hand-foot syndrome and granulocyte declining in treatment group were lower than those in control group( P 0.05 to P 0.01) . Conclusions:Oxaliplatin combined with capecitabine in the treatment of patients with gastric cancer is good effects，high safety and little influence on immunity，which can protect the T cell subgroup， conducive to the rehabilitation of patients，be worthy of being widely applied in clinic.