The expression of signal transducers 3 and activators of transcription 3 in osteosarcoma and its relationship with tumor microvascular density

CHEN Xiao-dong; ZHOU Xin-she; LI Zhao-cheng; MA Li

Journal of Bengbu Medical University > 2013 > 37(10): 1260-1263.

CHEN Xiao-dong, ZHOU Xin-she, LI Zhao-cheng, MA Li. The expression of signal transducers 3 and activators of transcription 3 in osteosarcoma and its relationship with tumor microvascular density[J]. Journal of Bengbu Medical University, 2013, 37(10): 1260-1263.

Citation:

The expression of signal transducers 3 and activators of transcription 3 in osteosarcoma and its relationship with tumor microvascular density

1.
1. Department of Orthopedics，The First Affiliated Hospital of Bengbu Medical College，Bengbu Anhui 233004;
2.
2. Department of Pathology，Bengbu Medical College，Bengbu Anhui 233030，China

More Information

Received Date: August 16, 2012

Graphical Abstract

Abstract

Abstract

Objective: To explore the expression of signal transducer and activator of transcription 3(STAT3) in osteosarcoma and its relationship with tumor microvascular density(MVD) . Methods: The STAT3 expression of 47 cases with osteosarcoma were detected by immunohistochemistry. The clinical data，pathological classification and clinical index of 47 cases were compared. MVD of osteosarcoma was counted. The correlation between the expression of STAT3 and MVD was analyzed. results: The exprssion of STAT3 was mainly in the cytoplasm. The expression levels of STAT3 in osteosarcoma were significantly higher than that in normal bone tissue(P ＜ 0. 01) . The expression levels of STAT3 in osteosarcoma with stage Ⅱa，Ⅱb and Ⅲ were significantly higher than those in stage Ⅰ(P ＜ 0. 01) , the expression of stage Ⅲ was significantly higher than stage Ⅱa and Ⅱb(P ＜ 0. 01) . The expression levels of STAT3 in invasive soft tissue were significantly higher than that in no-invasive soft tissue(P ＜ 0. 01) . The expression of STAT3 in osteosarcoma was positively correlated with MVD(P ＜ 0. 05) . Conclusions: The expression of STAT3 in osteosarcoma is correlated with tumor clinical stage and soft tissue invasion, and its expression is positively correlated with MVD. The high expression of STAT3 may play an important role in the development of osteosarcoma, and which is closely correlated to the angiogenesis of osteosarcoma.
- osteosarcoma,
- signal transducers and activators of transcription 3,
- tumor microvessel density,
- immunohistochemistry

FullText(HTML)

References (14)

References

[1]	Yang SF，Wang SN，Wu CF，et al. Altered p-STAT3 (tyr705 ) expression is associated with histological grading and intratumour microvessel density in hepatocellular carcinoma [J]. J Clin Pathol, 2007，6 0(6): 642-648.
[1]	[2] Gong W，Wang L，Yao JC，et al. Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer[J]. Clin Cancer res, 2005, 11(4): 1386-1393.
[2]	[3] Achcar rde O，Cagle PT, Jagirdar J. Expression of activated and latent signal transducer and activator of transcription 3 in 303 non-small cell lung carcinomas and 44 malignant mesotheliomas: possible role for chemotherapeutic intervention[J]. Arch Pathol Lab Med，2007，1 31(9): 1350-1360.
[3]	[4] Jing N，Tweardy DJ. Targeting Stat3 in cancer therapy[J]. Anticancer Drugs，2005，1 6(6): 601-607.
[4]	[5] Weerasinghe P，Garcia GE，Zhu Q，et al. Inhibition of Stat3 activation and tumor growth suppression of non-small cell lung cancer by G-quartet oligonucleotides[J]. Int J Oncol，2007，31 (1): 129-136.
[5]	[6] Aggarwal BB，Sethi G，Ahn KS, et al. Targeting signal-transducerand-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution[J]. Ann N Y Acad Sci, 2006，1 091: 151-169.
[6]	[7] Wei D，Le X，Zheng L，et al. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis[J]. Oncogene, 2003，2 2(3): 319-329.
[7]	[8] Jung JE，Lee HG，Cho IH, et al. STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells [J]. FASEB J，2005，1 9(10): 1296-1298.
[8]	[9] Wang M，Tan J，Coffey A, et al. Signal transducer and activator of transcription 3-stimulated hypoxia inducible factor-1 mediates estrogen receptor-alpha-induced mesenchymal stem cell vascular endothelial growth factor production[J]. J Thorac Cardiovasc Surg, 2009，1 38(1): 163-171.
[9]	[10] Huang W，Yu LF，Zhong J, et al. Stat3 is involved in angiotensin Ⅱ-induced expression of MMP2 in gastric cancer cells[J]. Dig Dis Sci，2009，5 4(10): 2056-2062.
[10]	[11] Lang SA，Schachtschneider P，Moser C，et al. Dual targeting of raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes[J]. Mol Cancer Ther，2008，7(11): 3509-3518.
[11]	[12] Choi JH，Ahn MJ，Park CK, et al. Phospho-Stat3 expression and correlation with VEGF，p53, and Bcl-2 in gastric carcinoma using tissue microarray[J]. APMIS，2006, 114(9): 619-625.
[12]	[13] Xie TX，Huang FJ，Aldape KD, et al. Activation of stat3 in human melanoma promotes brain metastasis[J]. Cancer res，2006，66 (6): 3188-3196.
[13]	[14] Fossey SL，Liao AT，McCleese JK，et al. Characterization of STAT3 activation and expression in canine and human osteosarcoma[J]. BMC Cancer，2009，9 (1): 81.

Cited By

Get Citation

XML

Article views (3120) PDF downloads (131)

Turn off MathJax

Article Contents

Abstract

References

The expression of signal transducers 3 and activators of transcription 3 in osteosarcoma and its relationship with tumor microvascular density

Abstract

References

Catalog

Export File

Citation

Format

Content