The association between serum N-terminal pro brain natriuretic peptide level and left ventricular hypertrophy in maintenance hemodialysis patients

JIANG Wei-jie; SONG Jin-ye; WANG Yue-mei

Journal of Bengbu Medical University > 2013 > 37(10): 1317-1320.

JIANG Wei-jie, SONG Jin-ye, WANG Yue-mei. The association between serum N-terminal pro brain natriuretic peptide level and left ventricular hypertrophy in maintenance hemodialysis patients[J]. Journal of Bengbu Medical University, 2013, 37(10): 1317-1320.

Citation:

The association between serum N-terminal pro brain natriuretic peptide level and left ventricular hypertrophy in maintenance hemodialysis patients

Department of Nephrology，Shibei Hospital，Zhabei District，Shanghai 200443，China

More Information

Received Date: February 04, 2013

Graphical Abstract

Abstract

Abstract

Objective: To investigate the relationship between serum N-terminal pro brain natriuretic peptide(NT-proBNP) levels and left ventricle mass index(LVMI) in maintenance hemodialysis(MHD) patients. Methods: A total of 81 MHD patients were recruited, and the serum NT-proBNP levels were measured，echocardiography was performed and LVMI was calculated. The serum NT-proBNP levels in 55 MHD patients with left ventricular hypertrophy(LVH) according to LVMI were observed dynamically before and after treament of candesartan and levocarnitine for 4 months, the correlation between serum NT-proBNP level and LVMI in these patients was analyzed. results: Both of the serum NT-proBNP level and LVMI in MHD patients were significantly higher than that in control group (P ＜ 0. 01) . The serum NT-proBNP level in MHD patients with LVH was significantly higher than that in the MHD patients without LVH(P ＜ 0. 01) , and was positively correlated with LVMI(P ＜ 0. 01) . After treatment of candesartan and levocarnitine for 4 months, both of the serum NT-proBNP level and LVMI were significantly decreased than before (P ＜ 0. 01) . Conclusions: The serum NTproBNP level was significantly increased in MHD patients，especially in patients with LVH，and was positive correlation with LVMI, serum NT-proBNP level may be used for assessment LVH in MHD patients.
- hemodialysis,
- N-terminal pro brain natriuretic peptide,
- left ventricle mass index,
- left ventricular hypertrophy

FullText(HTML)

References (14)

References

[1]	[2] Steiner J，Guglin M. BNP or NTproBNP? A clinician's perspective [J]. Int J Cardiol, 2008，1 29(1): 5-14.
[1]	Park SH，Lee SW，Lee SJ，et al. The associat ion between left ventricular hypertrophy and biomarkers in patients on continuous ambulatory peritoneal dialysis[J]. Korean Circ J, 2009, 39(11): 488-493.
[2]	[3] Wang AY，Lam CW，Yu CM，et al. N-terminal pro-brain natriuretic peptide: an independent risk predictor of cardiovascular congestion，mortality，and adverse cardiovascular outcomes in chronic peritoneal dialysis patients[J]. J Am Soc Nephrol，2007, 18(1): 321-330.
[3]	[4] Madsen LH，Ladefoged S，Corell P，et al. N-terminal pro brain natriuretic peptide predicts mortality in patients with endstage renal disease in hemodialysis[J]. Kidney Int，2007，71 (6 ): 548-554.
[4]	[5] Trap J，Prez A，Naval I，et al. Nt-proBNP in haemodialysis patients: a preliminary study[J]. Scand J Clin Lab Invest，2008, 68(5): 415-420.
[5]	[6] 李杰，张启蒙，范敏华. N 端脑钠肽水平对血液透析患者容量负荷的诊断价值[J]. 中国血液净化，2 011，1 0(7): 376-379.
[6]	[7] 黎磊石刘志红. 中国肾脏病学[M]. 北京: 人民军医出版社, 2008: 1328-1334.
[7]	[8] Morillas P，Castillo J，Quiles J，et al. Usefulness of NT-proBNP level for dignosing left ventricular hypertrophy in hypertensive patients: a cardiac maagnetic resonance study [J]. rev Esp Cardiol, 2008，6 1(9): 972-975.
[8]	[9] Melina G，Angeloni E，Benedetto U，et al. relationship between prosthesis-patient mismatch and pro-brain natriuretic peptides after aortic valve replacement[J]. J Heart Valve Dis，2010，19 (2): 171-176.
[9]	[10] Bargnoux AS，Klouche K，Fareh J，et al. Prohormone brain natriuretic peptide (proBNP ) ，BNP and N-terminal-proBNP circulating levels in chronic hemodialysis patients. Correlation with ventricular function, fluid removal and effect of hemodiafiltration[J]. Clin Chem Lab Med, 2008, 46(7): 1019-1024.
[10]	[11] Yamazaki M，Ogawa T，Tamei N, et al，relation of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and left atrial volume index to left ventricular function in chronic hemodialysis patients [J]. Heart Vessels，2011，2 6(4): 421-427.
[11]	[12] 郑寅，匡鼎伟，李海明，等. 维持性血透患者N 端脑钠肽水平的影响因素及其与心脏重构和心功能的关系[J]. 复旦学报, 2010, 37(3): 298-303.
[12]	[13] Spratt JC，Webb DJ，Shiels A，et al. Effects of candesartan on cardiac and arterial structure and function in hypertensive subjects[J]. J renin Angiotensin Aldosterone Syst, 2001，2(4): 227-232.
[13]	[14] 李旭，曹宁，韩敬明，等. 左卡尼汀对维持性血液透析患者左心肥厚的影响[J]. 实用医学杂志，2 009，2 5(5): 786-788.

Cited By

Get Citation

XML

Article views (3037) PDF downloads (130)

Turn off MathJax

Article Contents

Abstract

References

The association between serum N-terminal pro brain natriuretic peptide level and left ventricular hypertrophy in maintenance hemodialysis patients

Abstract

References

Catalog

Export File

Citation

Format

Content