Expression and significance of survival protein recombinant retroviral vector construction in diseases

Objective: To explore the expression and clinical significance of survival protein recombinant retroviral vector construction in diseases. Methods: One hundred and twenty healthy mice with close body weight were chosen by using random single-blind research method. The mice were given aristolochic acid to induce lymphocytoma,which was extracted for cell culture in vitro. In the control group,each mouse's lymphoma cell nutrient solution was added conventional normal antineoplastic drugs,while in the observation group it was added the dendritic cell nutrient protein recombinant retroviral vector. The cancer cell death and anticancer conditions in the lymphoma cell nutrient solution were compared and analyzed between the two groups. Results: In the observation group,The death rates for the cancer cell culture fluid with 60%- 79% and 80%- 100% oncocyte were 40. 83% and 29. 17% respectively,while they were 14. 17% and 3. 33% in the control group. The difference was significant( P 0. 01). The cell culture fluid of the observation group was significantly better than that of the control group in eliminating oncocyte with a total efficiency of 95. 83%,which was significantly higher than that of the control group( 51. 67%)( P 0. 01). Conclusions: The dendritic cells infected by the survival protein recombinant retroviral vector can effectively restrain the lymphoma cells growth and reproduction in some degree,and antagonize the lymphoma cell. They have certain positive meaning in the treatment of lymphocytoma.