The effects of different concentrations of Xiangdan injection on skin flap survival

TAO Si-yi; MA Hong-li; HU Gao; ZHOU Zhan-wei; QI Jing

Journal of Bengbu Medical University > 2012 > 36(12): 1415-1417.

TAO Si-yi, MA Hong-li, HU Gao, ZHOU Zhan-wei, QI Jing. The effects of different concentrations of Xiangdan injection on skin flap survival[J]. Journal of Bengbu Medical University, 2012, 36(12): 1415-1417.

Citation:

The effects of different concentrations of Xiangdan injection on skin flap survival

1.
1. Department of Emergency,
2.
2. Department of Plastic Surgery, The Second Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233040;
3.
3. Department of Epidemiology, Bengbu Medical College, Bengbu Anhui 233030, China

More Information

Received Date: November 06, 2011

Graphical Abstract

Abstract

Abstract

Objective: To invstigate the effects of different concentrations of the Xiangdan injection on the survival length of skin flap.Methods: Fifteen rabbits were randomly divided into 5 groups(group A,B,C,D and E),which were made a 16 cm 2 cm skin flap at back of rabbit, then the skin flap was in situ transplanted.Group A,B,C and D were given Xiangdan injection of 4 mlkgP＜/i＞-1P＜/i＞dP＜/i＞-1P＜/i＞with the concentration of 6%, 12%, 24%, and 48% respectively after operation,while group E was given normal saline as control.The skin flap survival status were recorded and the pathological changes were observed by HE stain in two weeks after operation.Results: The length of skin flat survival of group B and C were longer than that of group A,D and E(P＜0.01), and that of group E was the shortest.More fibrous proliferation and little tissue necrosis were found in group B and C, little fibrous proliferation and more tissue necrosis in group A and little fibrous proliferation and most tissue necrosis in group D and E under microscope.Conclusions: The 12%-24%concentrations of Xiangdan injection can improve the random skin flap survival.
- surgical flaps,
- Xiangdan injection,
- survival,
- lenth,
- concentration

FullText(HTML)

References (13)

References

[1]	[2] 邝巧玲.香丹注射液治疗冠心病心绞痛临床观察[J].中国中医急症,2006,15(5):454-455.
[1]	王炜.整形外科学[M].浙江:科学技术出版社,1999:103.
[2]	[3] 薛洪利,张国华,于春泳,等.香丹注射液治疗急性重型颅脑损伤的内皮素含量与临床疗效观察[J].国际神经病学神经外科学杂志,2009,36(6):492-498.
[3]	[4] 李广勋.中药药理毒理与临床[M].天津:天津科技翻译出版公司,1992:246-249.
[4]	[5] 曾彩雯,夏春华,熊玉卿.丹参及其制剂主要效应组分的药代动力学研究进展[J].中国临床药理学与治疗学,2011,16(2):237-240.
[5]	[6] 夏金根.香丹注射液辅治冠心病心绞痛的临床观察[J].临床合理用药杂志,2011,4 (1B):40-41.
[6]	[7] 仇锦春,廖清船,张永,等.香丹注射液对急性血瘀模型大鼠血液流变性及血小板聚集的影响[J].中国实验方剂学杂志,2011,17(4):137-139.
[7]	[8] 李斐,孟运莲.香丹注射液对大鼠脑缺血再灌注损伤的保护作用[J].中国现代药物应用,2010,4(1):25-27.
[8]	[9] 吴时达,王静,陈守春,等.香丹注射液对冠心病血瘀证内皮源性血管活性因子基因表达的影响[J].中西医结合学报,2004,2(2):94-96.
[9]	[10] 何志,仇树林.丹参对缺血再灌注损伤皮瓣成活率的影响 [J].中国组织工程研究与临床康复,2011,15(5):855-860.
[10]	[11] 黄璜,何欢,王丹辉,等.拆方研究降香总萜、降香黄酮、丹参酮在冠心丹参方中抗大鼠心肌细胞缺氧/复氧损伤作用[J].中国实验方剂学杂志,2012,18(2):191-194.
[11]	[12] 何志,仇树林.丹参对皮瓣缺血再灌注损伤的影响及机制[J].中国组织工程研究与临床康复,2010,14(53):10020－10025.
[12]	[13] 王明宁,林洪,胡琳,等.香丹注射液对大鼠骨髓间充质干细胞的增殖作用[J].华西药学杂志,2007,22(3):304-305.

Cited By

Get Citation

XML

Article views (3194) PDF downloads (115)

Turn off MathJax

Article Contents

Abstract

References

The effects of different concentrations of Xiangdan injection on skin flap survival

Abstract

References

Catalog

Export File

Citation

Format

Content