Expressions of c-myc and p27 protein in bladder urothelial cancinoma and their correlation

Objective: To observe the expressions of c-myc and p27 in bladder urothelial carcinoma and the correlation between them. Methods: The expression of c-myc and p27 in 63 cases of bladder urothelial cancinoma were detected using immunohistochemical method.Results: The positive expression of p27 was significantly lower in bladder urothelial carcinoma than that in normal tissues(P ＜0.01); the expression of c-myc was significantly higher in bladder urothelial carcinoma than that in normal tissues(P＜0.01).The expressions of p27 and c-myc were correlated with the stage and grade of the bladder urothelial cancinoma(P＜0.05 to P＜0.01).There was a highly significant negative correlation between the expressions of p27 and c-myc(P＜0.01).Conclusions: p27 and c-myc may be useful makers in judging the differential degree and prognosis of the bladder carcinoma.