The effect of repeated inhaling of 2.3% sevoflurane on learning and memory and the activity of acetylchalinesterase in young rats

Objective: To investigate the effects of repeated inhaling of 2. 3% sevoflurane on learning and memory in young rats. Methods: Sixty SD male rats were randomly divided into Con1,Con3,Con5,Sev1,Sev3 and Sev5 group( 10 rats each group). The group Con1,Con3 and Con5 inhaled oxygen( 0. 5 L / min) 1 hour every day for 1,3 and 5 days,respectively. The group Sev1,Sev3 and Sev5 inhaled the mixed gas of 2. 3% sevoflurane and oxygen( 0. 5 L / min) 1 hour every day for 1,3 and 5 days,respectively. Water maze test in all groups were implemented 7 days later after the last administration. The training number of rats with requiring standard,escaping latency period,the number of entering blind end and activity of acetylcholinesterase after behavioral experiment were observed. The effects of repeated inhaling of 2. 3% sevoflurane on learning and memory in young rats were observed after 7 days. Results: The differences of the training number of rats with requiring standard,escaping latency period,the number of entering blind end and activity of acetylcholinesterase in all groups were not statistical significance( P 0. 05). Conclusions: The repeated inhaling 2. 3% sevoflurane 1 hour every day for 5 days in young rats have no effects on their learning and memory founction after 7 days.