The mean platelet volume change of type 2 diabetic patient and its relation with diabetic nephropathy

Objective:To explore the mean platelet volume(MPV) change of platelet parameters in type 2 diabetic patient and its relation with diabetic nephropathy.Methods:The parameters of platelet count(PLT),mean platelet volume(MPV) platelet distribution width(PDW),triglyceride (TG),total cholesterol (TC),fasting plasma glucose (FPG),glycated hemoglobin (HbA1C),24 h microalbumin urine(24h-MAU) and serum creatinine(Scr) of 180 type 2 diabetic patients and 142 health physical examination people were measured.Results:The age,FPG,TG,MPV and PDW of type 2 diabetic patients were higher than that in healthy people,but for PLT,it was lower than that in healthy people(P 0.05 to P 0.01).In type 2 diabetic patients,the levels of PDW,24 h-MAU of MPV 11 fl group were higher than that in MPV11 fl group,but for PLT,it was lower than that in MPV11 fl group(P 0.05 to P 0.01).Conclusions:The MPV of type 2 diabetic patients is increased,and which is positively related to the severity of the diabetic nephropathy.