Correlation of severe coronary artery lesion with total ischemic burden value，heart rate variability and corrected QT interval dispersion

Objective: To measure the Objective: Total ischemic burden(TIB),heart rate variability(HRV) and corrected QT interval dispersion (QTcd) in patients with different clinical types of coronary heart disease， and investigate their correlation with the severity of coronary artery lesion. Methods: Objective: Total 131 patients undergoing coronary angiography were included. According Objective: To the results of coronary angiography and clinical hisObjective: Tory， the patients were divided inObjective: To stable angina pecObjective: Toris group (SAP group，n = 31),unstable angina Objective: Toris group(UAP group，n = 35) and acute myocardial infarction group(AMI group，n = 35) ; and 30 persons without coronary artery lesion by coronary angiography were included as control group(n = 30). TIB，HRV index(PNN50，SDNN，SDANN，RMSSD) and QTcd were assessed by 24-hour dynamic electrocardiogram in all groups. Gensini score was also calculated as a measure of the severity of coronary artery lesion， and the correlation between HRV index，TIB，QTcd Gensini score was evaluated. The incidence of ventricular tachycardia in different range of QTcd was compared among all groups. Results: HRV index in SAP group，UAP group and AMI group were lower than those in control group(P ＜ 0. 05 Objective: To P ＜ 0. 01). HRV index in UAP group were significantly lower than those in SAP group(P ＜ 0. 01). HRV index in AMI group were significantly lower than those in UAP group(P ＜ 0. 01). TIB in UAP group and AMI group was significantly higher than that in control group and SAP group(P ＜ 0. 01). TIB in AMI group was significantly higher than that in UAP group(P ＜ 0. 01). QTcd in SAP group，UAP group and AMI group was significantly higher than that in control group(P ＜0. 01). QTcd in UAP group and AMI group was significantly higher than that in SAP group(P ＜ 0. 01). QTcd in AMI group was significantly higher than that in UAP group(P ＜ 0. 01). Gensini score in UAP group and AMI group was significantly higher than that in SAP group (P ＜ 0. 01 ). Gensini score in AMI group was significantly higher than that in UAP group(P ＜ 0. 01). HRV index were all negatively correlated with Gensini score(P ＜0. 05). TIB and QTcd were positively orrelated with Gensini score (P ＜ 0. 05 ). The highest incidence of ventriculartachycardia was occurred when QTcd was more than 60 ms(P ＜ 0. 05). Conclusions: TIB，HRV index，QTcd and Gensini score were varied with the clinical type of coronary heart disease. The more serious coronary artery lesions were， the higher values of TIB and QTcd were， the lower values of HRV index were. The increased QTcd commonly led Objective: To a higher incidence of ventricular tachycardia. It should be paid more attentions about TIB，HRV and QTcd on assessing the severity and prognosis of patients with coronary heart disease.