Efficacy comparision of dezocine and pentazocine used in patient-controlled intravenous analgesia after laparoscopic hysterectomy

Objective: To observe the clinical efficacy of posObjective: Toperative patient-controlled intravenous analgesia(PCIA) with dezocine and pentazocine on patients receiving laparoscopic hysterecObjective: Tomy. Methods: Eighty patients(ASA classⅠorⅡ ) scheduled for elective laparoscopic hysterecObjective: Tomy were randomly divided inObjective: To dezocine group(group D，n = 40) and pentazocine group(group P，n = 40). Group D were administered 0. 4 mg /ml dezocine and group P 1. 8 mg /ml pentazocine both via 0. 9% sodium chloride injection 100 ml by PCIA. The procedure of PCA was as follows: loading dose set 2 ml， continuous infusion set 2 ml /h and bolus set 0. 5 ml with 15-minute lockout interval. The visual analogue score， ramsay sedation score， effective press times of the PCIA and adverse effects were determined and compared at 4，8, 16，24 and 48 hour after operation. Results: There were no significant differences in visual analogue score and effective press times of PCIA between the two groups(P ＞ 0. 05). The ramsay sedation score and ncidence of adverse events such as nausea， vomiting and somnolence were significantly lower in group D than in group P(P ＜ 0. 05 Objective: To P ＜ 0. 01). Conclusions: Dezocine can be safely administrated Objective: To patients undergoing laparoscopic hysterecObjective: Tomy via PCIA with equal analgesic efficacy as pentazocine but less adverse effects.